Beta-Glucan Breakdown | Digesting the Power of Mushrooms nammex

Beta-Glucan Breakdown | Digesting the Power of Mushrooms.

Did you know that not all mushroom supplements are created equal? Beta-glucans (β-glucans) are part of a host of powerful compounds that give functional mushrooms their unique and beneficial properties.

These natural compounds are found in mushrooms, yeasts, and certain grains – but mushrooms contain some of the most beneficial and thoroughly researched forms for your immune system. Think of β-glucans as your immune system’s personal trainers, helping to keep your natural defenses in top shape!

Diagram illustrating the functions of beta-glucan, a compound found in mushrooms and dietary supplements. It aids in digesting while offering benefits like lowering cholesterol, antioxidant properties, blood sugar regulation, antitumor effects, stress protection, immunomodulation, and radio protection.

Let’s dig in

β-glucans are naturally occurring polysaccharides – complex carbohydrate molecules found in various natural sources including mushrooms, yeasts, seaweed, and certain grains like oats and barley. Think of them as building blocks that make up cell walls in these organisms, much like bricks form the structure of a building.

What makes mushroom beta-glucans special?

While β-glucans exist in many forms, mushroom β-glucans have unique structural characteristics that set them apart. The β-glucans found in mushrooms have a specific molecular structure that’s different from those found in other sources. For example, mushroom β-glucans typically have a branched structure with both 1,3 and 1,6 linkages, while oat β-glucans have a simpler linear structure with 1,3 and 1,4 linkages.

Diagram illustrating four sources of beta-glucan: cereal, bacteria, seaweed, and mushrooms. Each source showcases distinct structural details surrounding a central title "Sources of Origin of Beta-Glucan," highlighting their role in digesting nutrients.

At Nammex, we’ve spent over four decades studying and analyzing β-glucans in mushrooms. Through our research and development program, we’ve validated specific testing methods to identify and measure these compounds in our extracts. This scientific approach allows us to ensure consistent quality and potency in our products. We continue to work on alternative methods of analysis for mushroom β-glucans through our partnership with Purity IQ utilizing Nuclear Magnetic Resonance technology.

Learn more about Purity-IQ‘s Mushroom β-Glucan Authentication and Quantification Using NMR Spectroscopy here.

NMR spectra of different mushroom species, such as Trametes versicolor, Ganoderma lingzhi, and Ophiocordyceps sinensis, are displayed in various colors to enhance comparative analysis, with a focus on beta-glucan content.

The importance of testing

Not all mushroom products contain the same levels of β-glucans. This is why testing is crucial. Through our analytical program, we’ve established what we call the “Nammex mushroom testing fingerprint” which includes β-glucan testing as an integral part of the matrix. This testing ensures that when you choose a Nammex product, you’re getting mushroom extracts with verified β-glucan content in addition to other important fungal compounds such as ergothioneine and ergosterol and other species specific markers for quality and potency. The methods of qualification used by the Nammex Lab are now being integrated into commercial labs, and standard setting organizations. Nammex is engaged in collaborative validation and method transfer with these organizations to continue setting the bar for quality in the Mushroom category.

Why source matters

The source, growing conditions and post harvest handling of mushrooms can significantly impact their quality. Nammex’s products are born from the Chinese Tradition of mushroom cultivation and processing that dates back thousands of years with the advantage of the technological advances China has made through massive investment in their farmers and specialty crops. We focus entirely on mushrooms, allowing us to specialize in maximizing the presence of these beneficial compounds in our extracts and it is all under Organic Certification, at scale and runs like a well oiled machine.

Understanding beta-glucan testing

When evaluating mushroom products, it’s important to know that β-glucan content can vary significantly. Looking at the top 5 species for Nammex’s 1:1 extracts; Lion’s Mane, Reishi, Chaga, Cordyceps,and Turkey Tail there is a range of no less than 8mg/g for Chaga and Cordyceps. Lion’s Mane has 30mg/g. Reishi has a specification of no less than 35mg/g and Turkey Tail is NLT 45mg/g. Nammex has a tradition of collaboration with mushroom analytical sciences and has long worked with the company Megazyme who specializes in carbohydrate testing and science. Dr. Barry McCleary its founder has a seminal paper published in the Journal of the AOAC which is a must read and an independent analysis of  β-glucan in Mushrooms and Mycelium fermented Grain; Measurement of β-Glucan in Mushrooms and Mycelial Products . The Nammex Lab uses the Megazyme K-YBGL kit as do other third party labs to validate β-glucan content. Nammex goes a step further and also runs the AOAC Starch Test in tandem when analyzing commercial products to determine the amount of carrier or grain in non Mushroom products made from mycelium fermented grain. The alpha-glucan (α-glucan) results tend to follow the starch results with high amounts of alpha and starch in all mycelium fermented grain products yet low to no starch in true mushroom products with β-glucans percentages as noted above, quite high.

Looking to the future

As research continues to advance our understanding of β-glucans, we remain committed to maintaining the highest standards in mushroom extract production. Our ongoing research and development efforts help us stay at the forefront of mushroom science and analysis. We continue our work with NMR and Purity IQ to be able to strengthen the integrity of testing by adding more complimentary and fit for purpose methods.

Through our commitment to quality and scientific analysis, we continue to lead the way in understanding and properly identifying these fascinating compounds in mushroom products.

If you have any questions on the above info, please shoot us a direct message. We would be happy to help.

China 2024: Cordyceps Farm Visit

Three men stand together on the Great Wall of China during their visit to China 2024. The man on the left wears a green shirt and red shorts, the middle man wears a black shirt and shorts, and the right man dons a patterned shirt and shorts.

We’ve just returned from visiting our mushroom growers in China. People told us how much they appreciated reading about our trip there last December, so we wanted to share some details of our most recent journey.

We traveled to Inner Mongolia, a 6-hour drive from Daxing Airport. Daxing is currently the largest airport in the world, and 12% of its energy consumption is powered by Solar energy from Huawei FusionSolar Smart PV Solution. This 5.61 MWp project pioneered the application of clean energy in civil aviation. After grid connection, 6.1 GWh of green energy will be fed into the power grid annually, which equals to 1,900 tons of standard coal saving while offsetting 966 tons of CO2 and 14.5 tons of SO2 footprints every year.

Along the drive were far off mountain ranges that had a high desert feel. We arrived at the hotel for a Traditional Zither performance before dinner. All meals are typically served family style with the food arriving very quickly. One of the specialties in Inner Mongolia is BBQ. Healthy dishes of various vegetables, noodles, rice, meat, fish, and of course lots of mushrooms are all served in various ways. Each person helps themselves to what looks good as the food goes by, and the food never stops coming. If you remark on how tasty something is, magically, another whole dish of it appears in front of you.

Cordyceps Growers

A worker wearing blue gloves is sorting and arranging dried cordyceps on a tray in a food processing area, preparing for the anticipated demand from visitors planning their visit to China in 2024.

When we arrived at one of our large Cordyceps growing locations, we garbed up in Tyvek sanitary suits and went through an airlock dust control chamber, then into the facility for a tour of operations. Workers were organized, and paid close attention to sanitation.

This facility had ozone water purification and reverse osmosis for water treatment. They primarily use wheat and rice substrates for producing these cordyceps mushrooms, with ours being solely grown on rice. A mixer and auto injector are used to add nutrient fortified water into the solid substrate in preparation for sterilization. The rice and water filled tubs spend 2.5 hours in an autoclave and then cool for 8 hours. After cooling, the substrate is inoculated with cordyceps mycelium, then incubated for 7 days. Once the substrate is colonized, it will spend 14 days in two different wavelengths of light spectrum. The mushrooms are then harvested. The total cultivation time is 50-75 days.

Two workers in protective clothing and masks sort shredded food into large bins on a stainless steel table in a processing facility during the latest visit. Bins and racks filled with similar food items are in the background, reminiscent of scenes anticipated for China 2024.

The mature mushrooms are harvested by hand. The cordyceps mushrooms are removed very easily from the substrate, so the harvest goes quite quickly. The mushrooms are immediately sorted, spread out on drying racks, and dried for 15 hours using forced hot air. The dried mushrooms are then packed and ready for shipment to our extraction facility.

For any mushroom grower, there’s always a focus on yields. More yield by time or input materials yields higher revenues but we balance this with making sure the quality stays high and for Cordyceps militaris, this means cordycepin content.

Strain selection and light conditions are the biggest factors for cordycepin, while always keeping a balance between yield and cordycepin content. This facility specializes in the optimization of cordycepin content through strain development and specialized growing techniques.. The facility has received several patents for their innovation, and their products have obtained numerous certifications for product quality and traceability.

Golden Oyster Mushroom Farm

A person in a green shirt inspects yellow mushrooms growing on shelves in a greenhouse during their visit to China.

An hour away from the cordyceps growing facility was an emerging specialty grower who had Golden Oyster (Pleurotus citrinopileatus) and Morel mushrooms under cultivation. These specialty crops offer the promise of more money for the farmer, consistent with China’s efforts to reduce poverty and build a monetarily stable middle class.

We were there for the final flush of Golden Oyster Mushroom at the tail end of its growing season. They were using the typical autoclavable bag shaped like a log. The sterilized substrate used for inoculation are corn stalks and wheat bran, which are cheap and readily available local biomass sources.

A cluster of yellow mushrooms grows in the middle of a large indoor cultivation area filled with white substrate bags. The background is dimly lit with numerous similar bags, reminiscent of what one might see on a visit to China in 2024.

Golden Oyster mushrooms grow fast; from the start of a flush at pinning and buttons to full mushrooms is only three days. They recently installed new heaters in the grow house to control temperature along with a brand-new boiler for heat generation. After they are hand harvested, the mushrooms are transferred to a separate processing facility less than 1km away for trimming, sorting, and drying.

While most of our time was spent on farms, we did take time when the opportunity was presented for some historical appreciation.

Like most visitors to China, we organized a trip to the Great Wall of China. The Mutianyu section of the Great Wall once stood as a northern barrier, safeguarding the capital and imperial tombs and is an older section of the wall built during the Ming Dynasty (1368–1644). The wall itself was awe inspiring and the pictures and even the best video footage fails to capture the millennia of history and human accomplishment. Photos can’t compare to putting your hand on a rock that was placed by another human over 1,000 years ago.

A section of the Great Wall of China runs through a lush, mountainous landscape, attracting many visitors walking along the wall. Plan your visit to China in 2024 and experience this breathtaking marvel firsthand.

China 2024: Turkey Tail Farm Visit

Three men stand together in a greenhouse, surrounded by hanging logs used for organic turkey tail mushroom cultivation. They are smiling and wearing casual clothing, including t-shirts and a baseball cap. Skye Chilton, Adam Chilton, Bill Chioffi at a mushroom farm cultivation facility for Nammex in ChinaOne theme we observed throughout the course of our recent visit to our mushroom growers in China was the emphasis on educating people in different aspects of the mushroom industry, from research to cultivation. With the recent efforts to lift more citizens out of poverty, the business of researching and growing quality mushrooms is being highlighted as a path to a better life. Because of China’s long history of medicinal use of functional mushrooms and the deep knowledge developed over centuries, this path to prosperity has significant appeal to many people beyond the financial motivation.

On this trip, in addition to the Cordyceps inspections we told you about last month, we checked on the Turkey Tail (Trametes versicolor) farms. Nammex has been collaborating on scaling up cultivation of this specialty crop for the last six years, and we’re pleased with the progress. The region, largely forested by mixed hardwood and pine species, is technically remote yet has a local population of over 800,000 counting all the smaller outlying villages servicing agroforestry forest production.

We finally met, in person, our master grower and his daughter-in-law, who oversee each farm manager. At 80 years old, our master grower has been cultivating mushrooms of various kinds for over 60 years. He holds several patents for his work on both processing equipment and certain strain developments. Due to much of his training and teachings over decades, the local area now produces hundreds of millions of mushroom logs of various species every year.

A large pile of dried, curled, and layered Nammex organic turkey tail mushrooms with various shades of beige and dark brown.

Turkey Tail mushroom has been used traditionally for immunomodulatory effects. Nammex has pioneered the production of this species and is the only supplier to offer a cultivated, certified organic source of this mushroom extract. As more consumers learn of its benefits, we expect demand to, at minimum, double over the coming years, thus our program to ensure that supply tracks demand. We continue to be impressed by the yields and quality of the finished product. Seeing the pride shown by the farmers in the work being done was also quite encouraging.

The first farm we toured has an annual production of 25 tons of dry Turkey Tail. The second farm we visited was a bit smaller than the first, with 20 grow houses producing about 12 tons of mushrooms annually. The final, third farm was much smaller but was working on their efficiency with 10 grow houses dedicated to Turkey Tail. Overall, we are looking at about 60-80 tons of dried turkey tail mushrooms this year, over double last year’s output. Ideally, we would like to get to over 200 tons annually, which should be attainable in the next 2-3 years. Our master grower still believes there’s additional optimization in the growing conditions to increase yield and reduce waste.A hand holding a dark brown, fan-shaped mushroom highlights the nammex organic turkey tail mushroom cultivation in an outdoor agricultural setting.

All the mushrooms were solar dried on the farm prior to storage for shipping to our extraction facility. The Turkey Tail is grown on local birch sawdust fortified with wheat bran, another local byproduct. All of these farms also grow wood ear mushrooms, one of the most popular species in China for food consumption, as one of their primary sources of income. These are organically grown, and the farmers rely solely on proper sterile technique and natural climate conditions in order to grow the best mushrooms.

Every farm we visited demonstrated a commitment to good agricultural practices, but his attention to even the smallest detail most people would not notice clearly displayed his passion and reverence for mushroom growing.

One hotel we lodged in during this trip had an herbal shop with large chunks of local Chaga and other mushrooms for sale, mostly polypores. They also had locally harvested 10+ year old Panax ginseng C.A. Meyer roots, individually packaged in red satin to display the human shaped thick roots with well-preserved terminal ends at a thread’s width. It takes time and care to harvest a large tendrilled root in its whole form, like an archeological dig to preserve the integrity of the artifact. We see this depth of care for traditional medicines in China time and time again. This attention to detail and dedication to quality are why Nammex has partnered with growers in China since our founding in 1989.

Rows of mushroom logs hanging vertically in an organic cultivation facility, with nammex turkey tail mushrooms thriving on the logs.

China 2023, A Report From the Field

In early December my brother Adam and I traveled to China on one of our customary visits to farms that grow our mushrooms and the facilities that process Nammex organic mushroom extracts. China has such a long history of growing and using mushrooms both for food and medicine, and it’s always inspiring to see how much care goes into growing and handling them. China is such a fascinating place to visit.

We noticed upon our arrival in Shanghai how quiet the airport was, particularly compared to Seoul. This confirms what we heard from industry colleagues, who reported that travel to China is about 10% of what it was before Covid. It was a dramatic change since our last visit in 2019. We then took one of China’s many high-speed trains, with speeds up to 330km/h, to southwestern Zhejiang province to visit our exclusive manufacturing partner’s brand new extraction factory that came online during Covid.

Two people in white coats standing in a factory conducting a report.

This state-of-art, organic, GMP facility meets all the necessary US regulations and is 3rd party audited every year. The facility has numerous extraction tanks and spray dryers that process thousands of kilos of dried mushrooms in storage here. There’s a fully staffed quality control team with their own floor where they’re able to run all the necessary tests to make sure our products meet specifications before leaving China. There are also solar panels on the roof that offset energy consumption, and power air conditioning in the hot summer months. Because demand for Nammex ingredients has grown massively, we work closely with our partners on raw material planning and finished extract projections to ensure that we can meet future growth. The current capacity can handle 500,000 kilos of extract powder a year, with multiple dried mushroom storage facilities nearby and land next door for future expansion.

A man holding a hedgehog in a greenhouse.

The next day we were off to Qingyuan County, one of China’s 17 key regions of global significance for biodiversity. For hundreds of years local residents have made thoughtful use of forest resources to cultivate mushrooms. They have developed an agroforestry system with mushroom and forest co-culture methods. The traditional knowledge and techniques were developed over centuries by “Gumin”, which is the name for farmers who cultivate mushrooms by integrating forest conservation and agricultural production while following the best aspects of ecological agriculture. The main focus is quality and sustainability. Qingyuan County produces around 20% of China’s mushrooms, employing over 70,000 people, and creating about one billion USD in economic output annually. If you would like to learn more about this area, the Food and Agriculture Organization of the United Nations has a good article.

A man standing in a field of pine cones in China.

Our first stop was to visit a farm that grows wood ear mushrooms (Auricularia heimuer). While this is a mushroom we do not currently sell, it is one of the most popular edible mushrooms in the world and does have functional benefits backed by extensive research. As with all our partners in China, their understanding of what these fungi need to grow into the high-quality mushrooms we require was remarkable. This farm was impressive in their attention to detail required for a robust harvest of quality mushrooms, quite similar to others we’ve seen in the past. It’s very common to put the colonized wood ear logs in the rice fields after the rice harvest, essentially performing crop rotations.

In 2023, a woman in China is picking mushrooms out of a crate for a report.

One of our nearby shiitake growers is also in this wooded, hilly rural area. They produce 12,000 kilos of fresh mushrooms from 1.3 acres, with a dozen or so people unwrapping the logs ready to fruit, picking mushrooms off the sawdust logs, trimming them, and laying them out to dry. After our time there, it was entirely appropriate to visit the Shiitake Temple, a place of worship for Wu Sangong, the first person to figure out how to cultivate shiitake mushrooms over 800 years ago. The temple, which was first built in 1265, holds a ceremony honoring him every July. Right next to the Shiitake Temple is one of Qingyuan’s famous wooden bridges. Both Zhejiang and Fujian provinces are very famous for their wooden bridges. Many are protected natural heritage sites.

A bridge over a river.

One of the many covered wooden bridges in Zhejiang and Fujian province.

From there we traveled to the Qingyuan Mushroom Market, which is the largest mushroom market in China. For people as obsessed with mushrooms as we are, this was an incredible place to walk around. This is probably a good time to share that on this trip we ate mushrooms every day at every meal, and ate over a dozen different wild and cultivated mushroom species, possibly more.

A plate with mushrooms and chopsticks on it, featured in a China 2023 report.The report captures a plate of Chinese food on a table, showcasing the culinary delights from China.

A pan of soup with mushrooms in it.

The next day we continued back into the mountains of Fujian province to Gutian County to visit the lion’s mane farms. While confirming quality and sustainability is always part of our purpose, we also wanted to check on scalability for this ingredient that is growing in popularity so fast. Nammex currently has over 3 million lion’s mane logs in production, across many different farms. One farm we toured had 80,000 logs growing. After harvesting, the spent sawdust logs are dried and used as fuel to power the mushroom dehydrators.

Two men standing in front of a room full of mushrooms.

December 7th we focused on tremella. While touring one farm with 60,000 logs growing this mushroom, we noticed that the mycelium is a distinctive black color. The temperature and humidity are closely controlled, as this mushroom does better in very high humidity. Nearby, we also saw nameko mushroom (Pholiota microsprora), which we hadn’t seen in cultivation before.

Field report on mushrooms growing on a log in a dark room.

Pholiota microsprora

The following day we moved on to cordyceps. These mushrooms need approximately 80 days from inoculation to harvest. Temperature and humidity in these grow rooms are tightly controlled, and the mushrooms are guided to maturity by LED lights.

Our next stop was in Songyang at a local government funded mushroom research institute. They have over 200 different lion’s mane strains in production to look for unique characteristics, and more than 100 strains of shiitake in cultivation. We also stopped in to see a tea R&D farm with over 10,000 tea plants growing. The day was rounded out by a stop in the ancient villages in Songyang, which were first built around 1655 and today house approximately 300 people.A tea plantation in a village.

An interesting fact we picked up along the way is that over 100,000 kilos of cultivated caterpillar fungus (Ophiocordyceps sinensis) is being produced today, although it has yet to bring the price of the wild version down.

On our final day we were back on the train to Shanghai, to spend time with our friend Professor Edward Yang, whose father invented PSP (Polysaccharide Peptide). PSP is a turkey tail mycelium extract which is produced through liquid fermentation and further purification. The end product is approved by the Chinese government as a drug. We’re bonded by being the sons of men whose lives have been devoted to making the benefits of mushrooms more accessible to people.

While the main purpose of our trip was to confirm the high quality we expect and continued supply of our ingredients as demand for Nammex products grows, the long history of reverence and dedication to mushrooms is inspiration we draw from, every day.

– Skye Chilton, CEO, Nammex

Two men standing in front of a pile of sacks.

FDA Issues 180-Day Interim Response to Citizen Petition

Nammex, the premier North American supplier of Certified Organic Functional Mushroom Extracts, has received an interim response from FDA to the Citizen Petition the company filed in June requesting the Agency address the mislabeling of dietary supplements and functional foods as “mushroom” or containing “mushrooms” when they contain other fungal parts, and do not contain “mushrooms” as claimed, or fail to disclose added grain ingredients.

“The FDA has 180 days to respond to this type of Citizen Petition and may approve, deny, or dismiss the petition, or provide an interim response indicating why the agency has not reached a decision, which is often due to competing agency priorities,” said Holly Bayne of the Law Office of Bayne & Associates, Nammex’s regulatory counsel. “We are pleased that FDA staff within the Office of Dietary Supplement Programs are continuing to evaluate the petition.”

Nammex filed the Citizen Petition advocating for full transparency in product labeling and urging companies in the industry to identify ingredients from fungi according to the part of the fungal organism from which they are derived, consistent with FDA’s labeling requirement for botanicals. The issues Nammex raised in the Citizen Petition have been discussed in the trade press, at conferences and trades shows, and even covered by Rolling Stone magazine.

“We understand that the agency has its hand full with the reorganization of the Human Foods Program and look forward to further engagement with FDA and a positive decision in 2024, especially given the rapid growth of the mushroom product category,” said Skye Chilton, CEO of Nammex. “As a recent survey of 10,000 people on mushroom terminology we commissioned showed, the vast majority of consumers have a specific idea of what constitutes a mushroom, and it’s the cap (and stem), not myceliated grain.”

The petition asked FDA to correct ambiguity in the dietary supplement labeling regulations to clarify that proper listing of ingredients from fungi on product labels includes identification of the part of the fungal organism from which the ingredient is derived. Nammex also requested that FDA issue industry guidance regarding the proper labeling of fungal ingredients, including a Glossary of Mycological terms. Further, Nammex requested that FDA increase regulatory enforcement to ensure foods and dietary supplements containing fungal ingredients are accurately labeled, and take appropriate action against products labeled as “mushroom” that actually contain other fungal parts, such as mycelium, and fail to identify the presence of grain in the product.

Survey of 10,000 People Confirms a Mushroom is a Mushroom

Nammex, the premier North American supplier of Certified Organic Functional Mushroom Extracts, commissioned a survey of 10,000 people in the US on mushroom terminology that makes the consumer’s definition of what a mushroom is clear: it’s a mushroom.

A diversity of mushrooms are arranged on a white background.

“We commissioned this survey as a logical extension of our campaign for clarity and accuracy in mushroom product labeling,” said Skye Chilton, Nammex CEO.  “While the industry debates whether or not it’s acceptable to state or imply that mycelium-containing products are mushrooms, we thought knowing what consumers actually think was important information for the industry to have.”

In the survey, respondents were asked if they knew what a “fruiting body” was; 71.5% said they did not know. They were then shown a photo of a variety of mushrooms and asked “what are these?” The percentage of people who identified them as “mushrooms” was telling: 90.1%. A further 12.3% identified them as fungi, and 2.8% as “fruiting body.”

A bag of rice on a wooden table.

The next photo showed mycelium growing on a grain substrate in a plastic bag, with the question “is this a mushroom?” While 20.7% identified the myceliated grain as a mushroom, 79.3% checked the “not a mushroom” box. The main reasons given by the people who identified the myceliated grain as a mushroom were the context of the survey or knowing mushrooms grow from mycelium from having used mushroom growing kits.

“This data confirms that the vast majority of consumers have a fairly specific idea of what constitutes a mushroom, and it’s not myceliated grain,” Skye said. “As we have said all along, to the industry and to FDA with our Citizen Petition asking for labeling clarity, it’s essential to be fair to consumers and not imply they are getting something they are not when they buy a product. It’s not only ethical, it protects the industry from losing their trust.”

Of the 10,000 respondents, 45% were male, and 55% were female. Ages were grouped from 18-34 (47.7%), 35-44 (23.3%), 45-54 (14.1%), and 55+ (14.6%). The survey was conducted in mid-2023 by the respected consumer research company Prolific.

Nammex Files Citizen Petition Requesting FDA Actions on Mushroom Product Labeling

Nammex, the premier North American supplier of Certified Organic Functional Mushroom Extracts, has filed a Citizen Petition with FDA requesting the Agency to address the mislabeling of dietary supplements and functional foods as “mushroom” or containing “mushrooms” when they contain other fungal parts, and do not contain “mushrooms” as claimed, or fail to disclose added grain ingredients.

For many years, Nammex has been advocating for full transparency in product labeling and urging companies in the industry to identify ingredients from fungi according to the part of the fungal organism from which they are derived, consistent with FDA’s labeling requirement for botanicals. While there has been some, although limited progress, in light of ambiguity in FDA’s labeling regulations and compliance policies, Nammex Founder Jeff Chilton decided that it was time to raise public awareness and request guidance as well as increased attention from FDA to ensure industry compliance.

Given the explosive growth the mushroom category is undergoing and entry of new companies marketing products with fungal ingredients that may not be aware of the regulatory requirements, it made sense to undertake this action now. We hope to raise awareness of the mislabeling problem that exists today in the US, and obtain FDA regulatory guidance on the labeling of mushrooms and other fungal ingredients to ensure truth-in-labeling,” Jeff said. “When consumers buy a product labeled as “mushroom”, they should feel confident that they are getting a genuine mushroom product.”

According to Nammex’s regulatory counsel, Holly Bayne of the Law Office of Bayne & Associates, “Citizen Petitions provide a public forum through which interested parties can request FDA to issue or amend a regulation or take other administrative action. As the petition has made clear, remedial action from FDA is warranted, including revisions to the Agency’s compliance policies to ensure foods and dietary supplements containing fungal ingredients are accurately labeled and not misbranded. We look forward to engaging with FDA on this important issue.”

The petition asks FDA to correct ambiguity in the dietary supplement labeling regulations to clarify that proper listing of ingredients from fungi on product labels includes identification of the part of the fungal organism from which the ingredient is derived. Nammex also requests that FDA issue industry guidance regarding the proper labeling of fungal ingredients, including a Glossary of Mycological terms. Further, Nammex requests that FDA increase regulatory enforcement to ensure foods and dietary supplements containing fungal ingredients are accurately labeled, and take appropriate action against products labeled as “mushroom” when they do not contain mushrooms as claimed, but contain other fungal parts, such as mycelium, and fail to identify the presence of grain in product.

The Agency has 180 days to respond to the petition. Nammex intends to keep the industry informed though out the process.

Nammex Achieves a Breakthrough in Mushroom Cultivation

Cultivated Turkey Tail is Available for the First Time

After three years of research and development, Nammex – an organic mushroom extract ingredient supplier – has achieved a breakthrough: Close to 80 tons of fresh Trametes versicolor, commonly known as turkey tail, have been cultivated and harvested for commercial purposes this year.

With that, Nammex is the first and only company in the world to cultivate turkey tail on a commercial basis. While wildcrafting is commercially viable in Asia, foraged mushrooms suffer quality issues – from differing substrates, adulteration with look-alike species, as well as possible mold contaminants and heavy metals accumulation.

turkey tail mushroom cultivation and growing

Nammex avoids issues associated with wildcrafting by growing turkey tail on an enriched sawdust substrate in an optimal growth environment; therefore, Nammex mushrooms are free from contaminating molds and insects, contain lower heavy metals, and are correctly identified 100% of the time.

“We’re able to harvest close to 80 tons now and plan to double that figure by next year,” says Nammex President, Jeff Chilton. “This will make a key organic mushroom extract exponentially more available to health and wellness companies that use our organic extracts in their branded retail products.”

Turkey tail, which has been used as an immune system potentiator in traditional Chinese medicine for hundreds of years, often grows wild in clusters on tree trunks and logs on both living and dead coniferous and deciduous trees. A small, thin-fleshed species with pores instead of gills, it can be found in temperate climatic zones all over the world. Although turkey tail can be cultivated on wood logs or sawdust, its small size and low overall yields have made commercial cultivation economically unfeasible until now.

Nammex continues to set standards in the functional mushroom category. From introducing organic mushroom extracts in 1998 and validating reishi triterpenes in the 2000s, to guaranteeing beta-glucan content in 2015 and cultivating a higher quality turkey tail mushroom in 2021, the company supplies health and wellness companies with superior organic mushroom extracts.

Learn more about our turkey tail mushroom extract ingredients.

The 10th International Medicinal Mushroom Conference

China Adventures 2019 – Medicinal Mushroom Conference Details

The 10th International Medicinal Mushroom Conference

This year our annual trip to China coincided with the 10th International Medicinal Mushroom Conference in Nantong, China. This event is held every 2 years in a different country and brings together mushroom scientists and researchers from around the world. Over 1000 scientists, researchers and industry professionals submitted papers and 150 were selected for presentations. Jeff Chilton submitted his current research on medicinal mushroom product quality and was accepted for an oral presentation. Here are a few of the highlights.

IMMC10 participants group photo

First, the Conference was preceded by a 1 day seminar with Professor Shu-Ting Chang, who is regarded as the godfather of medicinal mushrooms. He has spent well over 60 years promoting the cultivation of mushrooms as food and medicine. Professor Chang has over 220 published scientific papers and authored 23 books. He is also one the initiators and editors at the International Journal of Medicinal Mushrooms. In 2015, Dr. Chang quoted Jeff’s White Paper, Redefining Medicinal Mushrooms, in his keynote address to the Reishi Mushroom Association in China conference. Dr. Chang is currently 92 but still remains in good health and always has a smile on his face.

Professor Shu-Ting Chang

Mushroom Product Quality is Still a Major Issue

Professor Soloman Wasser’s Keynote opening presentation discussed the quality controls necessary for medicinal mushroom dietary supplements, based on S.T. Chang’s 5 G’s:

  • GLP – Good Laboratory Practices
  • GAP – Good Agriculture Practices
  • GMP – Good Manufacturing Practices
  • GPP – Good Production Practices
  • GCP – Good Clinical Practices

The Five "G" Guidelines

Nammex strictly follows these guidelines: growing mushrooms naturally using organic practices, processing the mushrooms following cGMP standards, QC testing in qualified laboratories, yearly audits of farm and factory, and final packaging by NSF certified contract manufacturers.

Dr. Lindequist References USP Reishi Report

Professor Ulrike Lindequist from Germany, a pharmacologist and specialist in biologically active compounds from mushrooms, plants and marine microorganisms, also discussed quality control. Her list of important Quality Control issues coincides with the Nammex industry changing White Paper, Redefining Medicinal Mushrooms, published in 2015, and the Nammex Testing Protocol. She also made note of the USP study of reishi products.

  • USP report that 74% of reishi products are not authentic
  • Use of validated analytical methods for testing
  • The need for suitable reference compounds and standards
  • Voucher specimens for reference materials
  • Proper taxonomical identification of species
  • Proper identification of the fungal stage: mushroom, mycelium, spore
  • Identification of substrate residues (ie. grains)
  • Proper testing for pesticides, heavy metals, microbiological contamination and adulterants like starch

Quality Problems

Jeff Chilton Presents Nammex Testing Protocol

Jeff Chilton gave a presentation on quality control for medicinal mushroom products, which was very well received. He outlined information published in the Nammex 2015 white paper and added new data on the use of ergosterol and ergothioneine as markers. All Nammex products are tested for these three most important active compounds: beta-glucans, ergosterol, and ergothioneine. A full video of the presentation will be released soon which we will embed here once it goes live.

Jeff also presented a paper that detailed the Megazyme beta-glucan test method, in place of Dr. Barry McCleary, CEO of Megazyme, who was unable to attend. The Megazyme test has become the de-facto standard for medicinal mushroom quality.

Jeff Chilton at IMMC10

Reishi Research in China

Professor Jingsong Zhang, Vice Chairman of the Chinese Society of Mycology, had an interesting talk on the level of research and production of reishi in China. He highlighted how much knowledge and understanding of mushrooms is still retained within China and the need for more collaboration with Western researchers.

  • Over 82% of reishi research is published in Chinese.
  • Four times more reishi research is published in Chinese than English, although English publications are now increasing at a faster rate. Could this be due to the increased awareness of medicinal mushrooms in North America?
  • There are 10,000 patents on reishi in China.
  • China grows over 200 million pounds of reishi per year (wow!)
  • Different strains of reishi are used for different purposes: spore production, polysaccharides, triterpenoid value

Mushroom Cultivation Progress

Cordyceps

Exciting new information and photos showed the cultivation of 91 different species of cordyceps. This opens up a whole new area of future research on possible new and unique medicinal compounds.

Not only that, but a new method for cultivating Ophiocordyceps sinensis was presented. This incredible break-through uses ghost moth larvae to mimic natural growing conditions. To date, the company who developed this technique has produced 10 tons of dried cordyceps and they are chemically consistent with the wildcrafted caterpillar fungus.

IMMC10 - Cordyceps

Morels

The Chinese have been working for the last 50 years on large scale cultivation of morels. While there are records showing cultivation as early as the 1880’s in France, no one has been able to do it on a large commercial scale. Until now. China has gone from 3 tons of dried morels in 2012 to now over 800 tons last year. An increase of 26000% in 6 years!

IMMC10 - Morels

Cauliflower Mushroom

We’ve heard rumours about this for a few years, finally we see a presentation of the cauliflower mushroom cultivation. They grow it in bottle culture with a plastic skirt to make the mushroom grow straight up, the same method used to grow the enoki mushroom. Hopefully in the future, production will increase and at some point we will be able to obtain organic sources for extraction as there is some interesting research on sparassis crispa. Not only that, it is a delicious edible!

IMMC10 - Cauliflower Mushroom

Chaga

In 2016 at ISMS in Amsterdam, we learned that the Finnish government was funding the development of chaga cultivation in their vast hectares of birch forests. Currently, anywhere from 6-30% of birch forests in Finland and Sweden are inflected with Chaga.

In Nantong, we met Eric and Otso of Kaapa Health. They work directly with forest owners in Finland to inoculate their birch forests with chaga. This creates a higher dollar value yield per acre than conventional birch timber, which is harvested for standard uses. The forest owners manage the forests and Kaapa purchases the harvested, dried chaga from them. Kaapa currently has over 100 hectares inoculated and expects to harvest over 100 tons of chaga by 2023.

Reishi Spores

At Nammex, we have strong reservations about the benefits of reishi spores, yet in China they are currently more popular than the mushroom itself. We’ve found most of the claims made for reishi spores to be unfounded and the scientific research to be unconvincing.

Some companies claim that 1kg of spores comes from 1 ton of reishi mushrooms, trying to make spores seem rare. But China is now producing a spore yield of well over 100% of the mushroom’s weight and newly developed reishi strains can produce higher amounts of spores, in one instance a 276% yield increase. We have personally visited many farms that collect spores and have measured 400 grams of spores from one mushroom! A single mushroom weighs only 80 grams. It was noted that reishi spore farmers earn 20% more than other agricultural industries (35k-56k USD per year).

IMMC10 - Reishi Spores

Mushrooms as Food Additives

Professor Miomir Niksic from Serbia showcased the use of mushrooms in different food and beverage products. Professor Niksic works at the University of Belgrade in their Institute of Food Technology.

Nammex has more and more customers producing food products with our mushroom extracts. We consider this an easy way for consumers to increase their mushroom intake and gain the benefits. Here are a few examples of the innovative way that Professor Niksic has used mushrooms in food products:

  • Add to yogurt to increase antioxidant activity
  • Add to pasta to increase antioxidant activity and decease glycemic response
  • Add to sausage, tuna, tomato paste, chicken pate, chicken soup, cream cheese to improve shelf life by inhibiting bacteria growth
  • Add reishi to beer to influence bitterness

IMMC10 - Mushrooms as Food Additives

Summary

One of the things we love about coming to China is eating so many mushrooms. All meals contain some mushroom dish whether it be a standalone dish like cold marinated wood ear, a stir fry, or any number of unique mushroom containing dish. On this trip we ate the following mushrooms: oyster, lions mane, reishi (in soup), king oyster, cordyceps, tremella, enoki, white beech (shimeji), morels, pines, maitake, shiitake, white button, schizophyllum and probably others we can’t name.

All in all it was a very fun conference. We learned a lot, connected with old friends, and made many new friends. We are looking forward to the next International Medicinal Mushroom Conference in Serbia 2021 and are very excited to have the next ISMS conference in Vancouver 2021.

IMMC10

Adam Chilton Meets Great Wall of Reishi

Nammex Testing Protocol Presented at Medicinal Mushroom Conference

Mushroom scientists from around the world gathered in Nantong, China, from September 19th-23rd, 2019, at the most recent ISMM conference on medicinal mushrooms. Sessions were divided into multiple categories: Biochemistry and Pharmacology, Nutritional and Medicinal Values, Biodiversity and Ethnomycology, and Cultivation.

Jeff Chilton IMMC10 Conference

 

Jeff Chilton, founder of Nammex, elaborated upon his previous presentation at the International Society of Mushroom Science conference in Amsterdam in 2016. Beta-glucan testing remains the Nammex primary standard, accompanied by ergosterol and ergothioneine. Using these three markers plus alpha-glucans (starch), Jeff created a fingerprint that can be utilized for quality control of commercial mushroom products.

Ergothioneine, an important new antioxidant primarily found in fungi, is now being tested and quantified in all Nammex extracts, a milestone in this category.

Jeff Chilton IMMC10 Conference Presentation

Jeff also presented research by Dr. Barry McCleary, founder of Megazyme, who was unable to attend. Dr. McCleary’s paper detailed the Megazyme beta-glucan testing method and its clear advantage for mushroom testing. Using this method, not only beta-glucans but also alpha-glucans (starches) can be determined. This means that various starch adulterants can be unmasked, an ongoing issue for mushroom products.

S.T. Chang, Professor Emeritus, a founding member of the organization, and godfather of medicinal mushrooms, was in attendance and taught a one day seminar. Professor Chang has been committed to the development and promotion of edible and medicinal mushrooms for over 60 years. In 2015, in a keynote presentation to the first Chinese Reishi Conference, Dr. Chang quoted information and charts from Jeff’s White Paper, Redefining Medicinal Mushrooms.